Researchers from the study have stated that “If you find it incredibly hard to lose weight, it is because the stored fat in the body is actively fighting against your efforts to burn it off at the molecular level”. All rodents increased their metabolic rate slightly when switched from a lower fat diet to a higher fat diet, but mice lacking the sLR11 protein showed significant increase in energy expenditure, and were able to burn calories faster, in comparison to mice that possessed the sLR11 protein-producing gene.
Body is made up of fat cells, some that store excess energy to release when required, and some called brown adipocytes, that help the body in the process of heat generation or thermogenesis.
Afterwards, it has been discovered that LR11 had a role in regulating the lipoprotein lipase, an enzyme that regulates the supply of lipid to brown adipose tissue, coordinating its vesicular transport.
In their paper the authors suggest that sLR11 helps fat cells resist burning too much fat during “spikes” in other metabolic signals following large meals or short term drops in temperature. Based on this promising discovery, we look forward to the Cambridge team’s future findings.
While explaining the functioning of the fat cells, study authors said that almost all the fat cells store energy in the body and they release it when needed or at the time of crisis. It resists weight loss by inhibiting thermogenesis, or a process of creating heat that helps melt the fat away.
The presence of this protein’s amount is dependent on the amount of fat in the body.
Researcher also noted that the amount of protein a person can have depends on how much fat is stored in that particular person’s body.
This comes as a confirmation for millions of fat people all over the world who until know haven’t had any idea why it is so hard for them to lose weight, despite their tremendous efforts. The study has also indicated that once weight is gained it is important to try to lose it as fast as possible in order to prevent physiological changes from occurring in the body, changes such as the secretion of the sLR11 protein.
Unfortunately, though, Pearson added that “an effective medicine to treat obesity, which safely manages weight loss is still some way off”.